Copper-transporting p-type ATPase 2 is a cisplatin-based chemoresistance marker in human oral squamous cell carcinoma Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University 2-D-3 Hitoshi Miyashita et al.
E ffects of mandible repositioning appliances on mislocation of the Division of Oral Rehabilitation Medicine, Department of Special Needs Dentistry, Showa University School of Dentistry, Tokyo, Japan 2-D-4 piezosurgery and an intraoperative RED system Department of Oral and Maxillofacial Surgery, Kochi Health Sciences Center 2-D-5 Koji Takahashi Endoscopically assisted intraoral LeFort II midfacial advancement using Shingo Hara et al.
T he use of bone scintigraphy in the diagnosis of BRONJ:Dynamic analysis of technetium-99m HMDP accumulation Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata 2-D-7 Tsuchimochi Makoto et al.
Seiwert Immunotherapy, enabling a patient s own immune system to attack a cancer, is a novel treatment modality that has shown activity in more than 20 cancer types.
Head and neck cancers show a prominent inflamed phenotype with tumor infiltrating lymphocytes, and is amenable to immunotherapy.
Responses are oftentimes more durable than what is observed with chemotherapy or targeted therapies, and the impact on survival is pronounced compared to standard treatments.
Combined with a favorable toxicity profile PD- agents have been approved in the US for treatment of head and neck cancer.
Finally we will look ahead at upcoming second generation combination immunotherapy approaches, with early data suggesting that continued progress is ahead for our patients with oral cavity cancers and head and neck cancers in general.
Seiwert did his medical training at Johannes Gutenberg University, Germany.
He completed two internships and subsequent residency in internal medicine at the University of Heidelberg, and Duke University, NC in the US.
For his fellowship training Dr.
Seiwert worked at the University of Chicago.
He was mentored by Dr.
Everett Vokes and Ravi Salgia with a focus on Head and Neck Cancer translational research.
He became Faculty at the University of Chicago in Dr.
Seiwert currently is the Associate Program Director for the Head and Neck Cancer Program.
He well known for his pioneering work in defining the HPV+ HNC genome, and translational and clinical work related to Immunobiology, and Immunotherapy in head and neck cancer.
Alton Jones Cell Science Center, NY, USA Dr.
Until now, clinical outcomes for OSCC using EGFR inhibitors as single agents have yielded disappointing results.
Here, we aimed to study whether combinatorial treatment using AG478 EGFR tyrosine kinase inhibitor and deguelin, which is a rotenoid isolated the African plant Mundulea sericea, could enhance the anti-tumor effect of AG478 in OSCC.
For Ca9-22 cells having EGFR, KRAS, and PIK3CA wild type, AG478 alone suppressed both phosphorylated levels of ERK and AKT and induced apoptosis.
On the contrary, for HSC-4 cells having EGFR and KRAS wild type, and PIK3CA mutant, AG478 alone did not either suppress phosphorylated level of AKT or induce apoptosis while it suppressed ERK phosphorylation.
Forced expression of constitutively active PIK3CA G633A mutation significantly reduced apoptotic effect of AG478 on the PIK3CA wild type Ca9-22 cells.
When HSC-4 cells having PIK3CA G633A mutation were treated with the combination of AG478 and deguelin, synergistic effect on apoptosis induction was observed through the inhibition of AKT pathway.
These results suggest that the combination of EGFR tyrosine kinase inhibitor with deguelin is a potential therapeutic approach to treat PIK3CA-mutated OSCC.
Objects Our aim of this study was to investigate if ATP7B is expressed in OSCC and whether its expression correlates with prognosis and reduced responsiveness to cisplatin treatment.
Materials and Methods Tumor tissues were obtained from 5 patients with OSCC who received cisplatinbased preoperative chemotherapy.
We performed immunohistochemical analysis using ATP7B monoclonal antibody in 5 OSCC and adjacent non-neoplastic link />We retrospectively examined the expression of ATP7B source primary OSCC and its association with chemotherapeutic effect and prognosis.
Results A variable degree of cytoplasmic staining of tumor cells was observed in 28 cases 54.
Conclusion These findings suggest that high levels of ATP7B expression are associated with unfavorable clinical outcome in patients with 0SCC.
ATP7B may be a cisplatin-based chemoresistance indicator in patients with OSCC.
We developed the mandible repositioning appliances MRAs for repositioning the deviation of the mandible.
The fabrication method and the effects of MRAs are introduced in this report.
Methods MRAs include maxillary and mandibular appliances.
The deviated mandible segment was moved manually toward go here normal position after the maxillary and mandible appliances were worn.
The appliances were fixed using dental resin material.
Patients wear the MRAs during sleep and for 3 hours a day for 2-3weeks.
Eight patients served as subjects.
We evaluated dysphagia score of the subjects using FOIS and Fujishima s Dysphagia Scale.
Results Eight patients showed improvement in eating ability, FOIS was from mean 4.
Conclusion Effectiveness 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 MRAs was verified for repositioning the deviated mandible resulting in improved eating ability chemotherapy.
Copper-transporting p-type ATPase 2 ATP7B 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 been reported to be associated with cisplatin resistance in vitro.
However, the clinical reconstruction may occur and release fixation of the mandible.
However, the conventional surgical method requires the coronal approach, including a coronal incision, together with other surgical approaches, such as an intraoral incision.
Therefore, surgeons often hesitate to propose this type of article source, even for patients who develop severe nonsyndromic midfacial-nose hypoplasia.
Objectives: This report presents a new surgical approach for performing a safe Le Fort II osteotomy for nasomaxillary, 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 corrective advancement via a solely intraoral approach.
Methods: Surgery was performed with endoscopically assisted piezoelectric surgery.
The osteotomized nasomaxillary Le Fort II segment was successfully protracted without aggressive downfracture procedures with the sole intraoperative use of a RED system, followed by internal rigid fixation, and the subsequent removal of the RED system.
Seven patients were included in this study.
Findings: The degrees of midfacial advancement at the base of nasal bone that was osteotomized and at maxillary point A was 8.
Conclusion: This new method less invasively facilitates safe, secure, and ideal nasomaxillary midfacial protraction to yield a satisfactory resultant facial profile and favorable occlusion in patients with severe midfacial-nose hypoplasia and skeletal see more III malocclusions.
Although one limitation of these resorbable fixation systems in the clinical setting was the complicated drill hole tapping, required for screw fixation.
The study included 28 consecutive patients 9 Male, 9 Female, mean age: 46.
The mean follow-up period was 9.
This material may be an optimal bioactive, osteoconductive, and bioresorbable bone alternative for orbital wall reconstruction with fewer complications in patients with orbital fractures.
Methods Forty patients who underwent bone scintigraphy with 99mTc-labeled hydroxymethylene diphosphonate 99mTc HMDP for diagnosis of bone disorders were entered into the study.
The patients were comprised of 6 BRONJ patients, 6 ORN patients, and 28 mandibular OM patients; 90 normal control subjects.
K and λ ratios reflecting bone blood flow and regional bone metabolism, respectively, were calculated.
The ratios of affected disease side to normal side were obtained.
Results The K-ratios mean ± SD were.
The λ -ratios were.
The K-ratio in BRONJ was significantly higher than that in normal subjects, but did not differ from that in OM.
The λ-ratio in BRONJ was low compared with OM, but increased compared with normal subjects.
There were similarities in both ratios between BRONJ and ORN.
Conclusions Dynamic analyses using a multicompartment model may help towards understanding and evaluation of bone disorders in Department of Oral and Maxillofacial Surgery, Saiseikai Yokohamashi Nanbu Hospital, 2Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine Noriaki Aoki, Yasufumi Kosugi, Masaki Iida, Hiromasa Endoh2, Junichi Baba2, Toshinori Iwai2, Iwai Tohnai2 Purpose The aim of this presentation is to show the previously unreported case of refixed the mobilized maxilla caused by fractured plate 8 months after LeFort I osteotomy.
Material and methods a 43-yearold man visited our hospital with a chief complaint of concave profile and malocclusion, following by underwent LeFort I and BSSRO.
Facial finding was symmetric and concave profile.
It was diagnosed as Skeletal III and Dental Class III with overclosure, severe anterior cross bite, low mandible and short face.
They were not filled with autogenous bone graft 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 LeFort I osteotomy, following by confirmed immobilization of the maxilla.
We have performed to refix the mobilized maxilla considering the maxillary segments.
Results One of titanium plates in the piriform margin completely fractured, although other titanium plates were not loosened.
read more addition, bone graft harvested from the mandibular ramus was placed with the screws in gap between maxillary segments.
BRONJ analysis of dynamic bone scintigraphy to evaluate bone disorders in BRONJ was employed.
Results They were aged from 30 to 57 years old.
The left side was involved in 4 patients and the right side in 2 patients.
Four patients had iatrogenic foreign this web page, including a dental implant, a maxillary wisdom tooth, a maxillary wisdom tooth root and a dental root canal filler.
The other two patients with non-iatrogenic foreign bodies fractured an interdental brush while cleaning 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 teeth and 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 entered the maxillary sinus.
For surgical extraction of foreign bodies, the intra-oral 骨髄腫 ボーナス 英語 メール 略語 医療脱毛 trans-nasal approaches were performed in 5 patients and patient, respectively.
· ・ MM （Multiple Myeloma）： 多発性骨髄腫 ・ NHL （Non-Hodgkin Lymphoma）： 非ホジキンリンパ腫 ・ PA （Pernicious Anemia.
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